18 Feb Can LDN make autoimmune disease worse?

LDN is rapidly metabolized and excreted from the body, within a few hours at most. Its beneficial effect in autoimmune disease is as result of it tricking the body into producing large amounts of OGF – which act as an immuno-suppressant/modulator. However, if the dose of LDN being used is too high, this making it Naltrexone treatment rather than Low Dose Naltrexone, it could definitely exacerbate the symptoms of autoimmune diseases. This is because the continuous presence of Naltrexone will block production of OGF on a continuous basis. OGF is needed to keep the immune system in order.